منابع مشابه
Lipid Lowering in Aortic Stenosis
Aortic valve stenosis (AS) is the end stage of an active fibrocalcific process with local inflammation, lipid deposition, fibrosis, and calcification as its key features.1 Adverse remodeling of a stenotic valve includes collagen deposition and elastin degradation, resulting from myofibroblast proliferation and activation, recruitment of inflammatory cells, and expression of proinflammatory cyto...
متن کاملIntensive lipid lowering with simvastatin and ezetimibe in aortic stenosis.
BACKGROUND Hyperlipidemia has been suggested as a risk factor for stenosis of the aortic valve, but lipid-lowering studies have had conflicting results. METHODS We conducted a randomized, double-blind trial involving 1873 patients with mild-to-moderate, asymptomatic aortic stenosis. The patients received either 40 mg of simvastatin plus 10 mg of ezetimibe or placebo daily. The primary outcome...
متن کاملSUPRAVALVAR AORTIC STENOSIS IN CHILDREN REPORT OF THIRTEEN CASES
During 15 years from 1975 to 1990, thirteen cases of supravalvar aortic stenosis were admitted at the pediatrics department of Shahid Rajai Heart Hospital, Tehran. All patients were subjected to cardiac catheterization and a angiocardiography. Patients ranged in age from 3.5 years to 14 years with a mean of 8.7 years. Seventy seven percent of childen were male. Eight cases (61.5%) had Wil...
متن کاملValvular Heart Disease Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis Results of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial
Background—Aortic stenosis (AS) is an active process with similarities to atherosclerosis. The objective of this study was to assess the effect of cholesterol lowering with rosuvastatin on the progression of AS. Methods and Results—This was a randomized, double-blind, placebo-controlled trial in asymptomatic patients with mild to moderate AS and no clinical indications for cholesterol lowering....
متن کاملStatins: Newer Roles Including Lipid Lowering Therapy
Statins are most effective pharmacologically agents to decrease total plasma cholesterol level by competitive inhibition of HMG-Co A reductase. Apart from the well-known LDL and cholesterol lowering effect, statins have been postulated to exert other beneficial effects also called pleotropic or non-lipid effects. Better understanding of various pleotropic effects of statins has prompted a new s...
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ژورنال
عنوان ژورنال: Circulation
سال: 2009
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.109.864421